Type 2 Inflammation Can Be An Underlying Cause Of Asthma
This underlying inflammation may be playing a role in your uncontrolled moderate-to-severe asthma.
With asthma caused by Type 2 inflammation, a patient's immune system may react excessively to environmental exposures. This can lead to increases in blood eosinophils and inflammation in the lungs that worsen asthma symptoms and trigger attacks.
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Asthma is defined as uncontrolled when a patient experiences 3-4 of the following symptoms in a 4-week span:
Daytime asthma symptoms more than twice a week
Rescue inhaler use more than twice a week
Missed or limited activities due to asthma
Oral corticosteroid (OCS) dependent asthma is asthma that is either uncontrolled or difficult-to-treat that relies on OCS in addition to other medications to:
Help treat or maintain good symptom control
Reduce the risk of asthma attacks
Eosinophilic asthma is a subtype of asthma that is often severe. It is often seen in adults who develop asthma in adulthood.
These patients have an increased amount of eosinophils present in their blood, lung tissue, and mucus coughed up from the respiratory tract.
Patients with this subtype of asthma do not typically have underlying allergies such as pollen, dust mites, smoke, and pet dander that trigger asthma symptoms.
What Can Cause asthma Attacks?
Hear from asthma specialist Dr Neil Jain
In this video, Dr Neil Jain answers common questions from asthma patients such as, “What are some underlying causes of an asthma attack?” and “How do I know if my asthma is being controlled?”
DUPIXENT is a prescription medicine used with other asthma medicines for the maintenance treatment of moderate-to-severe eosinophilic or oral steroid dependent asthma in adults and children 6 years of age and older whose asthma is not controlled with their current asthma medicines. DUPIXENT helps prevent severe asthma attacks (exacerbations) and can improve your breathing. DUPIXENT may also help reduce the amount of oral corticosteroids you need while preventing severe asthma attacks and improving your breathing. DUPIXENT is not used to treat sudden breathing problems. It is not known if DUPIXENT is safe and effective in children with asthma under 6 years of age.
Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.
Please see additional Important Safety Information throughout this video and adjacent links for full Prescribing Information.
Individual results with DUPIXENT may vary.
DR. JAIN: Most research suggests that asthma attacks may be caused by excess inflammation in the airways, which can lead to swelling of the airway, mucus production, and something called bronchoconstriction, where the airways clamp down, making it difficult to breathe. When you inhale something such as pet dander or other allergens, your immune system can react aggressively, and inflammation can increase.
This can worsen your asthma symptoms and cause an attack. Controlling the underlying inflammation in the lungs, regardless of whether you have any symptoms, may help prevent asthma attacks.
DR. JAIN: If your asthma is well controlled, you should be able to do most of the things you want to do without being limited by your breathing, and you should not need to use a rescue medication more than once a week. You should not need oral or injected steroids for asthma exacerbations or attacks more than once in a year, and you should not be waking up at night more than once a month due to asthma symptoms.
DR. JAIN: DUPIXENT may be an option to treat uncontrolled moderate-to-severe asthma, as long as there is evidence for inflammation called eosinophilic present or you have oral steroid dependent asthma. Your doctor may do some bloodwork to see if eosinophilic inflammation is present prior to starting DUPIXENT. Before starting DUPIXENT, you should talk to your doctor about all the medical conditions you have and the medications you are taking.
You and your doctor should also discuss the potential benefits and risks of treatment, including the most common side effects such as injection site reactions, and some serious side effects including allergic reactions that can sometimes be severe, inflammation of your blood vessels, and joint aches and pain.
Information and Indication
Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.
Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:
- have a parasitic (helminth) infection
- are scheduled to receive any vaccinations. You should not receive a "live vaccine" right before and during treatment with DUPIXENT.
- are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
- are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Especially tell your healthcare provider if you are taking oral, topical, or inhaled corticosteroid medicines or use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.
DUPIXENT can cause serious side effects, including:
- Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms: breathing problems or wheezing, swelling of the face, lips, mouth, tongue, or throat, fainting, dizziness, feeling lightheaded, fast pulse, fever, hives, joint pain, general ill feeling, itching, skin rash, swollen lymph nodes, nausea or vomiting, or cramps in your stomach-area.
- Inflammation of your blood vessels. Rarely, this can happen in people with asthma who receive DUPIXENT. This may happen in people who also take a steroid medicine by mouth that is being stopped or the dose is being lowered. It is not known whether this is caused by DUPIXENT. Tell your healthcare provider right away if you have: rash, chest pain, worsening shortness of breath, a feeling of pins and needles or numbness of your arms or legs, or persistent fever.
- Joint aches and pain. Some people who use DUPIXENT have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.
The most common side effects in patients with asthma include injection site reactions, high count of a certain white blood cell (eosinophilia), pain in the throat (oropharyngeal pain), and parasitic (helminth) infections.
Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an injection given under the skin (subcutaneous injection). Your healthcare provider will decide if you or your caregiver can inject DUPIXENT. Do not try to prepare and inject DUPIXENT until you or your caregiver have been trained by your healthcare provider. In children 12 years of age and older, it’s recommended DUPIXENT be administered by or under supervision of an adult. In children 6 to less than 12 years of age, DUPIXENT should be given by a caregiver.
DUPIXENT is a prescription medicine used with other asthma medicines for the maintenance treatment of moderate-to-severe eosinophilic or oral steroid dependent asthma in adults and children 6 years of age or older whose asthma is not controlled with their current asthma medicines. DUPIXENT helps prevent severe asthma attacks (exacerbations) and can improve your breathing. DUPIXENT may also help reduce the amount of oral corticosteroids you need while preventing severe asthma attacks and improving your breathing. DUPIXENT is not used to treat sudden breathing problems. It is not known if DUPIXENT is safe and effective in children with asthma under 6 years of age.
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